Ine Tijdens | Toxicology

Universiteit Leiden

Ine Tijdens

Position:

Research Technician

Telephone number: +31 (0)71 527 6271
E-mail address: tijdens@lacdr.leidenuniv.nl
Faculty/Unit: Faculty of Science, Leiden/Amsterdam Center for Drug Research, Toxicology
Office address: Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
roomnumber HB 704/HB 929

Biography: I’m connected to the Division of Toxicology of the LACDR since 1984, where I have various general assisting tasks within the molecular and cell biological research. I’m the contactperson for the use of the phosphor & fluorescence imager Typhoon 9400, and the 96-wells plate multilabel platereader FluorSTAR Optima.

2011

Hendriks, G., Atallah, M., Raamsman, M., Morolli, B., van der Putten, H., Jaadar, H., Tijdens, I, Esveldt-van Lange, R., Mullenders, L., van de Water, B., Vrieling, H. , Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment, Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, vol. 709-710, pp. 49-59.

2008

de Graauw, M., Tijdens, I, Smeets, M.B., Hensbergen, P.J., Deelder, A.M., van de Water, B. , Annexin A2 phosphorylation mediates cell scattering and branching morphogenesis via cofilin Activation, Mol Cell Biol, vol. 28, no. 3, pp. 1029-40.

2007

de Graauw, M., Le Dévédec, S., Tijdens, I, Smeets, M.B., Deelder, A.M., van de Water, B. , Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary cultured rat renal proximal tubular cells, J Pharmacol Exp Ther, vol. 322, no. 1, pp. 89-100.

2006

van Nimwegen, M.J., Huigsloot, M., Camier, A., Tijdens, I.B., van de Water, B. , Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells, Mol Pharmacol, vol. 70, no. 4, pp. 1330-9.

2005

de Graauw, M., Tijdens, I, Cramer, R., Corless, S., Timms, J.F., van de Water, B. , Heat shock protein 27 is the major differentially phosphorylated protein involved in renal epithelial cellular stress response and controls focal adhesion organization and apoptosis, J Biol Chem, vol. 280, no. 33, pp. 29885-98.

2003

Huigsloot, M., Tijdens, R.B., van de Water, B. , Inhibition of protein kinase Calpha enhances anticancer agent-induced loss of anchorage-independent growth regardless of protection against apoptosis by Bcl-2, Mol Pharmacol, vol. 64, no. 4, pp. 965-73.

2002

Huigsloot, M., Tijdens, I.B., Mulder, G.J., van de Water, B. , Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells, J Biol Chem, vol. 277, no. 39, pp. 35869-79.

2001

van de Water, B., Houtepen, F., Huigsloot, M., Tijdens, I.B. , Suppression of chemically induced apoptosis but not necrosis of renal proximal tubular epithelial (LLC-PK1) cells by focal adhesion kinase (FAK). Role of FAK in maintaining focal adhesion organization after acute renal cell injury, J Biol Chem, vol. 276, no. 39, pp. 36183-93.

Huigsloot, M., Tijdens, I.B., Mulder, G.J., van de Water, B. , Differential regulation of phosphatidylserine externalization and DNA fragmentation by caspases in anticancer drug-induced apoptosis of rat mammary adenocarcinoma MTLn3 cells, Biochem Pharmacol, vol. 62, no. 8, pp. 1087-97.

2000

van de Water, B., Tijdens, I.B., Verbrugge, A., Huigsloot, M., Dihal, A.A., Stevens, J.L., Jaken, S., Mulder, G.J. , Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells, J Biol Chem, vol. 275, no. 33, pp. 25805-13.

1998

van Beerendonk, G.J., Klein, J.C., Tijdens, R.B., Lichtenauer-Kaligis, E.G., Tasseron-de Jong, J.G., Meerman, J.H. , Lack of mammalian mutagenicity of the potent bacterial mutagen tris(2,3-dibromopropyl) phosphate and its metabolite 2-bromoacrolein, Mutat Res, vol. 415, no. 3, pp. 201-11.

1997

Bol, S.A., de Groot, A.J., Tijdens, R.B., Meerman, J.H., Mullenders, L.H., van Zeeland, A.A. , Electrochemical detection and quantification of the acetylated and deacetylated C8-deoxyguanosine DNA adducts induced by 2-acetylaminofluorene, Anal Biochem, vol. 251, no. 1, pp. 24-31.

1992

Nagelkerke, J.F., de Bont, A., de Bont, H.J., Tijdens, I.B., Mulder, G.J., Meerman, J.H. , Fasting increases the susceptibility of rat hepatocytes to the cytotoxic effects of N-hydroxy-acetylaminofluorene. Effects on mitochondrial respiration and membrane potential, Biochem Pharmacol, vol. 44, no. 12, pp. 2339-45.

1989

van de Poll, M.L., Tijdens, R.B., Vondracek, P., Bruins, A.P., Meijer, D.K., Meerman, J.H. , The role of sulfation in the metabolic activation of N-hydroxy-4'-fluoro-4-acetylaminobiphenyl, Carcinogenesis, vol. 10, no. 12, pp. 2285-91.

1988

Mulder, G.J., Nagelkerke, J.F., Tijdens, R.B., Wijnands, W.J., Van der Mark, E.J. , Inhibition of the oxidative metabolism of theophylline in isolated rat hepatocytes by the quinolone antibiotic enoxacin and its metabolite oxoenoxacin, but not by ofloxacin, Biochem Pharmacol, vol. 37, no. 13, pp. 2565-8.

1987

van den Goorbergh, J.A., de Wit, H., Tijdens, R.B., Mulder, G.J., Meerman, J.H. , Prevention by thioethers of the hepatotoxicity and covalent binding to macromolecules of N-hydroxy-2-acetylaminofluorene and its sulfate ester in rat liver in vivo and in vitro, Carcinogenesis, vol. 8, no. 2, pp. 275-9.

Nagelkerke, J.F., Tijdens, R.B., Schwarz, E.P., Winters, M.F., Paul, L.C., Mulder, G.J. , The covalent binding of cyclosporin A to rat liver macromolecules in vivo and in vitro: the role of cytochrome P-450, Toxicology, vol. 47, no. 3, pp. 277-84.

Kroese, E.D., Tijdens, R.B., Mulder, G.J., Meerman, J.H. , Autoradiographic studies on in vivo covalent binding of N-hydroxy-2-acetylaminofluorene in rat liver containing gamma-glutamyltranspeptidase-positive foci. The effect of the sulfation-inhibitor pentachlorophenol, Carcinogenesis, vol. 8, no. 4, pp. 571-5.

1986

Meerman, J.H., Tijdens, R.B., Mulder, G.J. , The binding of reactive metabolites of the carcinogen N-hydroxy-2-acetylaminofluorene to DNA and protein in isolated rat liver nuclei: effects of glutathione and methionine, J Biochem Toxicol, vol. 1, no. 2, pp. 1-10.

1985

Meerman, J.H., Tijdens, R.B. , Effect of glutathione depletion on the hepatotoxicity and covalent binding rat liver macromolecules of N-hydroxy-2-acetylaminofluorene, Cancer Res, vol. 45, no. 3, pp. 1132-9.

15/09/2011

Toxicology